Restylane® Refyne provides subtle support to help smooth out the lines that run alongside the corners of the mouth, such as nasolabial folds, and the flexibility needed for natural-looking movement and expressions.1,4,7
Restylane® Defyne provides flexibility and more support to help smooth out deeper lines around the mouth, such as nasolabial folds, while allowing natural-looking facial expressions 
Your provider will select which option is best for you.